pentobarbital will boost the amount or influence of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of ivosidenib with potent CYP3A4 inducers lowered ivosidenib plasma concentrations.pentobarbital will minimize the level or influence of etoposide by affecting hepatic/intest